GUIDANCE ON TEMPORARY DISCONTINUATION AND OVERDOSE

Temporary discontinuation

Breaks in therapy should be avoided wherever possible. However, in an instance where a temporary discontinuation is unavoidable (e.g. before a surgical intervention or invasive procedure), LIXIANA® should be restarted as soon as possible.

Overdose

Overdose with LIXIANA® may lead to haemorrhage. A specific antidote antagonising the pharmacodynamic effect of LIXIANA® is not available. Early administration of activated charcoal may be considered in case of LIXIANA® overdose to reduce absorption. This recommendation is based on standard treatment of drug overdose and data available with similar compounds, as the use of activated charcoal to reduce absorption of LIXIANA® has not been specifically studied in the LIXIANA® clinical programme.

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